The inner-nuclear-envelope protein emerin regulates HIV-1 infectivity

Jean-Marc Jacque and Mario Stevenson ()
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Jean-Marc Jacque: Program in Molecular Medicine, University of Massachusetts Medical School
Mario Stevenson: Program in Molecular Medicine, University of Massachusetts Medical School

Nature, 2006, vol. 441, issue 7093, 641-645

Abstract: Blocking HIV When the AIDS virus HIV-1 infects a macrophage, thereby reducing the cell's effectiveness in the immune response, it integrates viral cDNA into the chromatin. This suggests that the cell's nuclear membrane could be critical to the infection process. That is confirmed with the finding that HIV has difficulty infecting the macrophages lacking emerin, a component of the inner nuclear envelope. Small molecules that inhibit the interaction between emerin and viral cDNA might therefore help block HIV infection.

Date: 2006
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DOI: 10.1038/nature04682

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