Assembly of the inner rod determines needle length in the type III secretion injectisome

Thomas C. Marlovits, Tomoko Kubori, María Lara-Tejero, Dennis Thomas, Vinzenz M. Unger and Jorge E. Galán ()
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Thomas C. Marlovits: Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine
Tomoko Kubori: Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine
María Lara-Tejero: Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine
Dennis Thomas: Howard Hughes Medical Institute, Rosenstiel Basic Medical Sciences Research Center, Brandeis University
Vinzenz M. Unger: Yale University School of Medicine
Jorge E. Galán: Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine

Nature, 2006, vol. 441, issue 7093, 637-640

Abstract: Needle match The needle complex or ‘injectisome’ that transfers proteins from bacteria to eukaryotic cells is a virulence factor in many bacterial pathogens. A new study of the Salmonella typhimurium injectisome throws light on the mechanism by which ‘needles’ are produced with the appropriate length.

Date: 2006
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DOI: 10.1038/nature04822

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