Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential

Yousheng Shu, Andrea Hasenstaub, Alvaro Duque, Yuguo Yu and David A. McCormick ()
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Yousheng Shu: Kavli Institute for Neuroscience, Yale University School of Medicine
Andrea Hasenstaub: Kavli Institute for Neuroscience, Yale University School of Medicine
Alvaro Duque: Kavli Institute for Neuroscience, Yale University School of Medicine
Yuguo Yu: Kavli Institute for Neuroscience, Yale University School of Medicine
David A. McCormick: Kavli Institute for Neuroscience, Yale University School of Medicine

Nature, 2006, vol. 441, issue 7094, 761-765

Abstract: A slice of the action Rapid communication between the neurons of the cerebral cortex involves propagation of an action potential, but the assumption that this is the sole form of cortical neuronal communication may need revision. Whole-cell recordings point to a possible alternative mechanism. Changes in membrane potential, such as those associated with synaptic activity, can also propagate along axons and can significantly alter the average amplitude of postsynaptic potentials. This type of neuronal signal may have important consequences, for instance in conditions such as sensory stimulation, the waking-to-sleeping transition and epileptic seizure, where large membrane potential changes occur.

Date: 2006
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DOI: 10.1038/nature04720

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