Sleep in Drosophila is regulated by adult mushroom bodies

William J. Joiner, Amanda Crocker, Benjamin H. White and Amita Sehgal ()
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William J. Joiner: Center for Sleep and Respiratory Neurobiology
Amanda Crocker: Center for Sleep and Respiratory Neurobiology
Benjamin H. White: National Institute of Mental Health
Amita Sehgal: Center for Sleep and Respiratory Neurobiology

Nature, 2006, vol. 441, issue 7094, 757-760

Abstract: Sleep regulation The fruitfly Drosophila is well established as a genetic model for the study of sleep. The flies have a behavioural pattern resembling what we call sleep, but the signature EEG changes characteristic of sleep and its stages have not been identified, so it is not possible to say if sleep in flies is a neural process and, if so, what neural substrates are involved. Answering this question is an essential step towards interpreting the mechanisms by which genes influence sleep. Two groups have now tackled the problem, and both identify the structures known as the mushroom bodies as the part of the brain involved in sleep regulation. This discovery brings a neural dimension to sleep in Drosophila and also links sleep to the other known functions of the mushroom bodies — learning and memory.

Date: 2006
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DOI: 10.1038/nature04811

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