Germline transmission of genetically modified primordial germ cells

Marie-Cecile van de Lavoir, Jennifer H. Diamond, Philip A. Leighton, Christine Mather-Love, Babette S. Heyer, Renee Bradshaw, Allyn Kerchner, Lisa T. Hooi, Terri M. Gessaro, Susan E. Swanberg, Mary E. Delany and Robert J. Etches ()
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Marie-Cecile van de Lavoir: Origen Therapeutics
Jennifer H. Diamond: Origen Therapeutics
Philip A. Leighton: Origen Therapeutics
Christine Mather-Love: Origen Therapeutics
Babette S. Heyer: Origen Therapeutics
Renee Bradshaw: Origen Therapeutics
Allyn Kerchner: Origen Therapeutics
Lisa T. Hooi: Origen Therapeutics
Terri M. Gessaro: University of California
Susan E. Swanberg: University of California
Mary E. Delany: University of California
Robert J. Etches: Origen Therapeutics

Nature, 2006, vol. 441, issue 7094, 766-769

Abstract: Primordial germ cells (PGCs) can be isolated from chicken blood, propagated in culture indefinitely, and genetically modified to make transgenic chickens — in addition, the chicken PGCs can be induced in vivo to differentiate into embryonic germ cells that contribute to somatic tissues.

Date: 2006
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DOI: 10.1038/nature04831

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