Nuclear pore association confers optimal expression levels for an inducible yeast gene

Angela Taddei, Griet Van Houwe, Florence Hediger, Veronique Kalck, Fabien Cubizolles, Heiko Schober and Susan M. Gasser ()
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Angela Taddei: Friedrich Miescher Institute for Biomedical Research
Griet Van Houwe: University of Geneva, NCCR Frontiers in Genetics
Florence Hediger: Friedrich Miescher Institute for Biomedical Research
Veronique Kalck: Friedrich Miescher Institute for Biomedical Research
Fabien Cubizolles: Friedrich Miescher Institute for Biomedical Research
Heiko Schober: Friedrich Miescher Institute for Biomedical Research
Susan M. Gasser: Friedrich Miescher Institute for Biomedical Research

Nature, 2006, vol. 441, issue 7094, 774-778

Abstract: In the right place It is becoming clear that the position of genes within the nucleus can influence their expression, and two groups this week report examples of this in yeast. Cabal et al. find that activation of GAL genes confines them to the nuclear periphery. And Taddei et al. report that simply moving the HXK1 gene, by blocking or encouraging its association with the nuclear periphery, significantly alters gene expression.

Date: 2006
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DOI: 10.1038/nature04845

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