Loss of autophagy in the central nervous system causes neurodegeneration in mice

Masaaki Komatsu, Satoshi Waguri, Tomoki Chiba, Shigeo Murata, Jun-ichi Iwata, Isei Tanida, Takashi Ueno, Masato Koike, Yasuo Uchiyama, Eiki Kominami and Keiji Tanaka ()
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Masaaki Komatsu: Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku
Satoshi Waguri: Osaka University Graduate School of Medicine
Tomoki Chiba: Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku
Shigeo Murata: Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku
Jun-ichi Iwata: Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku
Isei Tanida: Juntendo University School of Medicine, Bunkyo-ku
Takashi Ueno: Juntendo University School of Medicine, Bunkyo-ku
Masato Koike: Osaka University Graduate School of Medicine
Yasuo Uchiyama: Osaka University Graduate School of Medicine
Eiki Kominami: Juntendo University School of Medicine, Bunkyo-ku
Keiji Tanaka: Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku

Nature, 2006, vol. 441, issue 7095, 880-884

Abstract: A tidy cell is a healthy cell Two papers this week suggest that the process of protein degradation and clearance of cellular components may be more important in maintaining the health of the nervous system than was thought. Both groups show that inhibition of autophagy in mouse brain cells results in neurodegeneration and early death. Autophagy, the protein degradation and recycling of cellular components, is important for the normal growth and development of a cell. The finding that the continual clearance of cellular components is essential for maintaining neuronal health should open up new avenues of research into the nature of neurodegenerative diseases.

Date: 2006
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DOI: 10.1038/nature04723

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