Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Taichi Hara, Kenji Nakamura, Makoto Matsui, Akitsugu Yamamoto, Yohko Nakahara, Rika Suzuki-Migishima, Minesuke Yokoyama, Kenji Mishima, Ichiro Saito, Hideyuki Okano and Noboru Mizushima ()
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Taichi Hara: Tokyo Metropolitan Institute of Medical Science
Kenji Nakamura: Mitsubishi Kagaku Institute of Life Sciences
Makoto Matsui: Tokyo Metropolitan Institute of Medical Science
Akitsugu Yamamoto: Nagahama Institute of Bio-Science and Technology
Yohko Nakahara: Mitsubishi Kagaku Institute of Life Sciences
Rika Suzuki-Migishima: Mitsubishi Kagaku Institute of Life Sciences
Minesuke Yokoyama: Niigata University
Kenji Mishima: Tsurumi University School of Dental Medicine
Ichiro Saito: Tsurumi University School of Dental Medicine
Hideyuki Okano: Keio University School of Medicine
Noboru Mizushima: Tokyo Metropolitan Institute of Medical Science

Nature, 2006, vol. 441, issue 7095, 885-889

Abstract: A tidy cell is a healthy cell Two papers this week suggest that the process of protein degradation and clearance of cellular components may be more important in maintaining the health of the nervous system than was thought. Both groups show that inhibition of autophagy in mouse brain cells results in neurodegeneration and early death. Autophagy, the protein degradation and recycling of cellular components, is important for the normal growth and development of a cell. The finding that the continual clearance of cellular components is essential for maintaining neuronal health should open up new avenues of research into the nature of neurodegenerative diseases.

Date: 2006
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DOI: 10.1038/nature04724

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