Signal peptide peptidase is required for dislocation from the endoplasmic reticulum

Joana Loureiro, Brendan N. Lilley, Eric Spooner, Vanessa Noriega, Domenico Tortorella and Hidde L. Ploegh ()
Additional contact information
Joana Loureiro: Department of Pathology
Brendan N. Lilley: Department of Pathology
Eric Spooner: Pathology Functional Proteomics Center, Harvard Medical School
Vanessa Noriega: Mount Sinai School of Medicine
Domenico Tortorella: Mount Sinai School of Medicine
Hidde L. Ploegh: Department of Pathology

Nature, 2006, vol. 441, issue 7095, 894-897

Abstract: As well as cleaving hydrophobic stretches of amino acids in the plane of the cell membrane, the protease signal peptide peptidase plays a role in the disposal of unwanted glycoproteins from the endoplasmic reticulum — indicating that these proteases may be important for general membrane protein quality control.

Date: 2006
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DOI: 10.1038/nature04830

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