CRD-BP mediates stabilization of βTrCP1 and c-myc mRNA in response to β-catenin signalling

Felicite K. Noubissi, Irina Elcheva, Neehar Bhatia, Abbas Shakoori, Andrei Ougolkov, Jianghuai Liu, Toshinari Minamoto, Jeff Ross, Serge Y. Fuchs and Vladimir S. Spiegelman ()
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Felicite K. Noubissi: University of Wisconsin School of Medicine and Public Health
Irina Elcheva: University of Wisconsin School of Medicine and Public Health
Neehar Bhatia: University of Wisconsin School of Medicine and Public Health
Abbas Shakoori: Cancer Research Institute, Kanazawa University
Andrei Ougolkov: Cancer Research Institute, Kanazawa University
Jianghuai Liu: University of Pennsylvania
Toshinari Minamoto: Cancer Research Institute, Kanazawa University
Jeff Ross: University of Wisconsin School of Medicine and Public Health
Serge Y. Fuchs: University of Pennsylvania
Vladimir S. Spiegelman: University of Wisconsin School of Medicine and Public Health

Nature, 2006, vol. 441, issue 7095, 898-901

Abstract: β-catenin stabilizes the mRNA encoding the F-box protein βTrCP1, and the RNA-binding protein CRD–BP (coding region determinant-binding protein) is identified as a previously unknown target of β-catenin/Tcf transcription factor.

Date: 2006
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DOI: 10.1038/nature04839

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