Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium

Simona W. Rossi, William E. Jenkinson, Graham Anderson () and Eric J. Jenkinson
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Simona W. Rossi: Institute for Biomedical Research, Medical School, University of Birmingham
William E. Jenkinson: Institute for Biomedical Research, Medical School, University of Birmingham
Graham Anderson: Institute for Biomedical Research, Medical School, University of Birmingham
Eric J. Jenkinson: Institute for Biomedical Research, Medical School, University of Birmingham

Nature, 2006, vol. 441, issue 7096, 988-991

Abstract: Immune responses: two for T The thymus is the main source of T cells that form a major pillar of immune defence against viruses and cancerous cells. It is composed of two epithelial cell types — cortical and medullary — each of which performs distinct tasks in T-cell selection. Whether the two compartments arise from distinct or common progenitors has been controversial. Two groups, working separately, now show that there is a common progenitor for the two tissue types. The fact that a single precursor with stem-cell-like properties can generate both tissues provides hope for the viability of cell-based therapies for thymic disorders.

Date: 2006
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DOI: 10.1038/nature04813

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