Smad4 signalling in T cells is required for suppression of gastrointestinal cancer

Byung-Gyu Kim, Cuiling Li, Wenhui Qiao, Mizuko Mamura, Barbara Kasperczak, Miriam Anver, Lawrence Wolfraim, Suntaek Hong, Elizabeth Mushinski, Michael Potter, Seong-Jin Kim, Xin-Yuan Fu, Chuxia Deng and John J. Letterio ()
Additional contact information
Byung-Gyu Kim: National Cancer Institute, National Institutes of Health
Cuiling Li: Genetics of Disease and Development Branch, National Institutes of Diabetes & Digestive & Kidney Diseases, National Institutes of Health
Wenhui Qiao: Genetics of Disease and Development Branch, National Institutes of Diabetes & Digestive & Kidney Diseases, National Institutes of Health
Mizuko Mamura: National Cancer Institute, National Institutes of Health
Barbara Kasperczak: SAIC, National Cancer Institute-Frederick
Miriam Anver: SAIC, National Cancer Institute-Frederick
Lawrence Wolfraim: National Cancer Institute, National Institutes of Health
Suntaek Hong: National Cancer Institute, National Institutes of Health
Elizabeth Mushinski: Center for Cancer Research, The National Institutes of Health
Michael Potter: Center for Cancer Research, The National Institutes of Health
Seong-Jin Kim: National Cancer Institute, National Institutes of Health
Xin-Yuan Fu: Indiana School of Medicine
Chuxia Deng: Genetics of Disease and Development Branch, National Institutes of Diabetes & Digestive & Kidney Diseases, National Institutes of Health
John J. Letterio: National Cancer Institute, National Institutes of Health

Nature, 2006, vol. 441, issue 7096, 1015-1019

Abstract: Defective TGF-βsignalling in epithelial cells of the intestine can lead to cancer — a selective defect in this pathway in T cells also promotes the formation of gastrointestinal tumours, due to aberrant cytokine production.

Date: 2006
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DOI: 10.1038/nature04846

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