Formation of a functional thymus initiated by a postnatal epithelial progenitor cell

Conrad C. Bleul, Tatiana Corbeaux, Alexander Reuter, Paul Fisch, Jürgen Schulte Mönting and Thomas Boehm ()
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Conrad C. Bleul: Max-Planck Institute of Immunobiology
Tatiana Corbeaux: Max-Planck Institute of Immunobiology
Alexander Reuter: Max-Planck Institute of Immunobiology
Paul Fisch: University of Freiburg
Jürgen Schulte Mönting: University of Freiburg
Thomas Boehm: Max-Planck Institute of Immunobiology

Nature, 2006, vol. 441, issue 7096, 992-996

Abstract: Immune responses: two for T The thymus is the main source of T cells that form a major pillar of immune defence against viruses and cancerous cells. It is composed of two epithelial cell types — cortical and medullary — each of which performs distinct tasks in T-cell selection. Whether the two compartments arise from distinct or common progenitors has been controversial. Two groups, working separately, now show that there is a common progenitor for the two tissue types. The fact that a single precursor with stem-cell-like properties can generate both tissues provides hope for the viability of cell-based therapies for thymic disorders.

Date: 2006
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DOI: 10.1038/nature04850

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