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Nanog promotes transfer of pluripotency after cell fusion

José Silva, Ian Chambers, Steven Pollard and Austin Smith ()
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José Silva: University of Edinburgh
Ian Chambers: University of Edinburgh
Steven Pollard: University of Edinburgh
Austin Smith: University of Edinburgh

Nature, 2006, vol. 441, issue 7096, 997-1001

Abstract: Fusion of cultured pluripotent embryonic stem cells with somatic cells is used to show that raising the levels of the transcription factor Nanog stimulates pluripotent gene activation from the somatic cell genome. Thus Nanog plays a dominant role in controlling pluripotent gene expression or chromatin remodeling.

Date: 2006
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DOI: 10.1038/nature04914

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