Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

Ira E. Clark, Mark W. Dodson, Changan Jiang, Joseph H. Cao, Jun R. Huh, Jae Hong Seol, Soon Ji Yoo, Bruce A. Hay and Ming Guo ()
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Ira E. Clark: Brain Research Institute, The David Geffen School of Medicine, University of California
Mark W. Dodson: Brain Research Institute, The David Geffen School of Medicine, University of California
Changan Jiang: Brain Research Institute, The David Geffen School of Medicine, University of California
Joseph H. Cao: Brain Research Institute, The David Geffen School of Medicine, University of California
Jun R. Huh: California Institute of Technology
Jae Hong Seol: Seoul National University
Soon Ji Yoo: Kyung Hee Institute of Age-related and Brains Disease, Kyung Hee University
Bruce A. Hay: California Institute of Technology
Ming Guo: Brain Research Institute, The David Geffen School of Medicine, University of California

Nature, 2006, vol. 441, issue 7097, 1162-1166

Abstract: Parkin penalty The PINK1 gene was recently implicated in autosomal recessive juvenile Parkinson's disease. Two groups have studied the equivalent gene in the fruitfly Drosophila, and find that it localizes to mitochondria in vivo and is essential to mitochondrial function. It also interacts genetically with parkin, another familial Parkinson's disease-related gene that encodes Parkin, an E3 ubiquitin ligase. The pink1-parkin pathway in Drosophila should provide a powerful tool for the study of the molecular mechanisms of neurodegeneration and for screening agents of possible therapeutic interest.

Date: 2006
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DOI: 10.1038/nature04779

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