Asymmetric and symmetric stem-cell divisions in development and cancer

Sean J. Morrison () and Judith Kimble ()
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Sean J. Morrison: Howard Hughes Medical Institute and Life Sciences Institute, and Center for Stem Cell Biology, University of Michigan
Judith Kimble: University of Wisconsin-Madison

Nature, 2006, vol. 441, issue 7097, 1068-1074

Abstract: Abstract Listen to an interview with Sean Morrison on the stem cells podcast Much has been made of the idea that asymmetric cell division is a defining characteristic of stem cells that enables them to simultaneously perpetuate themselves (self-renew) and generate differentiated progeny. Yet many stem cells can divide symmetrically, particularly when they are expanding in number during development or after injury. Thus, asymmetric division is not necessary for stem-cell identity but rather is a tool that stem cells can use to maintain appropriate numbers of progeny. The facultative use of symmetric or asymmetric divisions by stem cells may be a key adaptation that is crucial for adult regenerative capacity.

Date: 2006
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DOI: 10.1038/nature04956

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