Stem cells, ageing and the quest for immortality

Thomas A. Rando ()
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Thomas A. Rando: Geriatric Research, Education and Clinical Center (GRECC), VA Palo Alto Health Care System, Stanford University School of Medicine

Nature, 2006, vol. 441, issue 7097, 1080-1086

Abstract: Abstract Listen to an interview with Tom Rando on the stem cells podcast Adult stem cells reside in most mammalian tissues, but the extent to which they contribute to normal homeostasis and repair varies widely. There is an overall decline in tissue regenerative potential with age, and the question arises as to whether this is due to the intrinsic ageing of stem cells or, rather, to the impairment of stem-cell function in the aged tissue environment. Unravelling these distinct contributions to the aged phenotype will be critical to the success of any therapeutic application of stem cells in the emerging field of regenerative medicine with respect to tissue injury, degenerative diseases or normal functional declines that accompany ageing.

Date: 2006
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DOI: 10.1038/nature04958

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