Generation of neuronal variability and complexity

Alysson R. Muotri and Fred H. Gage ()
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Alysson R. Muotri: Laboratory of Genetics, The Salk Institute for Biological Studies
Fred H. Gage: Laboratory of Genetics, The Salk Institute for Biological Studies

Nature, 2006, vol. 441, issue 7097, 1087-1093

Abstract: Abstract Listen to an interview with Fred Gage on the stem cells podcast The production of specialized differentiated neurons derived from stem cells has been proposed as a revolutionary technology for regenerative medicine. However, few examples of specific neuronal cell differentiation have been described so far. Although stem-cell tissue replacement might be seemingly straightforward in other cases, the high degree of complexity of the nervous system raises the challenge of tissue replacement substantially. Understanding mechanisms of neuronal diversification will not only be relevant for therapeutic purposes but might also shed light on the differences in cognitive abilities, personality traits and psychiatric conditions observed in humans.

Date: 2006
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DOI: 10.1038/nature04959

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