Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript

A. Gupta, J. J. Gartner, P. Sethupathy, A. G. Hatzigeorgiou and N. W. Fraser ()
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A. Gupta: University of Pennsylvania School of Medicine
J. J. Gartner: University of Pennsylvania School of Medicine
P. Sethupathy: University of Pennsylvania School of Medicine
A. G. Hatzigeorgiou: University of Pennsylvania School of Medicine
N. W. Fraser: University of Pennsylvania School of Medicine

Nature, 2006, vol. 442, issue 7098, 82-85

Abstract: How herpes simplex hides Herpes simplex virus 1 (HSV-1) can lie latent in the peripheral nervous system until reactivated by stress of some kind, when infectious viruses are again produced, forming familiar epithelial herpes infections such as cold sores. Just one viral gene is expressed during this latency phase, and no viral particles are produced. The product of that one gene has now been identified and the subtlety of the latency ploy is revealed: the virus produces a microRNA that protects the infected neurons from cell death (or apoptosis), so that the infection persists until reactivated. Mammalian cells are known to use the RNAi (RNA interference) pathway to restrict viral propagation but here the tables are turned to the benefit of the virus.

Date: 2006
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DOI: 10.1038/nature04836

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