Selective elimination of messenger RNA prevents an incidence of untimely meiosis

Yuriko Harigaya, Hirotsugu Tanaka, Soichiro Yamanaka, Kayoko Tanaka, Yoshinori Watanabe, Chihiro Tsutsumi, Yuji Chikashige, Yasushi Hiraoka, Akira Yamashita and Masayuki Yamamoto ()
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Yuriko Harigaya: Graduate School of Science
Hirotsugu Tanaka: Graduate School of Science
Soichiro Yamanaka: Graduate School of Science
Kayoko Tanaka: Graduate School of Science
Yoshinori Watanabe: Graduate School of Science
Chihiro Tsutsumi: Kansai Advanced Research Center, National Institute of Information and Communications Technology
Yuji Chikashige: Kansai Advanced Research Center, National Institute of Information and Communications Technology
Yasushi Hiraoka: Kansai Advanced Research Center, National Institute of Information and Communications Technology
Akira Yamashita: University of Tokyo, Hongo
Masayuki Yamamoto: Graduate School of Science

Nature, 2006, vol. 442, issue 7098, 45-50

Abstract: Abstract Much remains unknown about the molecular regulation of meiosis. Here we show that meiosis-specific transcripts are selectively removed if expressed during vegetative growth in fission yeast. These messenger RNAs contain a cis-acting region—which we call the DSR—that confers this removal via binding to a YTH-family protein Mmi1. Loss of Mmi1 function severely impairs cell growth owing to the untimely expression of meiotic transcripts. Microarray analysis reveals that at least a dozen such meiosis-specific transcripts are eliminated by the DSR–Mmi1 system. Mmi1 remains in the form of multiple nuclear foci during vegetative growth. At meiotic prophase these foci precipitate to a single focus, which coincides with the dot formed by the master meiosis-regulator Mei2. A meiotic arrest due to the loss of the Mei2 dot is released by a reduction in Mmi1 activity. We propose that Mei2 turns off the DSR–Mmi1 system by sequestering Mmi1 to the dot and thereby secures stable expression of meiosis-specific transcripts.

Date: 2006
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DOI: 10.1038/nature04881

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