Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography

Jun Liu, Dianne W. Taylor, Elena B. Krementsova, Kathleen M. Trybus () and Kenneth A. Taylor ()
Additional contact information
Jun Liu: Florida State University
Dianne W. Taylor: Florida State University
Elena B. Krementsova: University of Vermont
Kathleen M. Trybus: University of Vermont
Kenneth A. Taylor: Florida State University

Nature, 2006, vol. 442, issue 7099, 208-211

Abstract: Myosin V: special delivery There is growing interest in the mechanisms that cells use to deliver specific components to correct sites. Myosin motor proteins perform many of these transport roles. Now Liu et al. have determined the three-dimensional structure of an inhibited state of myosin V: the structure suggests a novel mechanism for solving the problem of returning a molecular motor from its destination to its starting position. When myosin V has no cargo it has a compact structure that binds to rapidly treadmilling actin filaments. In a separate paper, Thirumurugan et al. show that, in the absence of cargo, the cargo-binding domain of myosin V binds to a specific target on its own motor domain to inhibit its own movement along the actin track and weaken its binding to actin. These two papers reveal the elegant method used by cells to keep cargo transport under control.

Date: 2006
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/nature04719 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:442:y:2006:i:7099:d:10.1038_nature04719

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature04719

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().