Does prepatterning occur in the mouse egg? (Reply)

Berenika Plusa, Anna-Katerina Hadjantonakis, Dionne Gray, Karolina Piotrowska-Nitsche, Agnieszka Jedrusik, Virginia E. Papaioannou, David M. Glover and Magdalena Zernicka-Goetz ()
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Berenika Plusa: University of Cambridge
Anna-Katerina Hadjantonakis: Developmental Biology Program, Sloan-Kettering Institute
Dionne Gray: University of Cambridge
Karolina Piotrowska-Nitsche: University of Cambridge
Agnieszka Jedrusik: University of Cambridge
Virginia E. Papaioannou: College of Physicians and Surgeons, Columbia University
David M. Glover: University of Cambridge
Magdalena Zernicka-Goetz: University of Cambridge

Nature, 2006, vol. 442, issue 7099, E4-E4

Abstract: Abstract Hiiragi et al .1 compare our model2 of the developing mouse egg with theirs3. They seem to present patterning as equivalent to determination, but this is confusing as patterning does not have to mean determination. We have never stated that mouse embryo development is determined. Mouse development is regulative rather than determinative, and this can be explained in two ways: first, development could be entirely unbiased, generating identical cells; second, there could be some developmental bias or, in other words, pattern from the beginning that is not constraining. There is evidence for early bias from several laboratories2,4,5,6,7,8 but this does not mean that cells have localized determinants fixing their fates. Regulative development does not exclude bias, which indicates inclination, not determination.

Date: 2006
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DOI: 10.1038/nature04908

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