A novel class of small RNAs bind to MILI protein in mouse testes

Alexei Aravin, Dimos Gaidatzis, Sébastien Pfeffer, Mariana Lagos-Quintana, Pablo Landgraf, Nicola Iovino, Patricia Morris, Michael J. Brownstein, Satomi Kuramochi-Miyagawa, Toru Nakano, Minchen Chien, James J. Russo, Jingyue Ju, Robert Sheridan, Chris Sander, Mihaela Zavolan () and Thomas Tuschl ()
Additional contact information
Alexei Aravin: The Rockefeller University
Dimos Gaidatzis: Biozentrum, Universität Basel
Sébastien Pfeffer: The Rockefeller University
Mariana Lagos-Quintana: The Rockefeller University
Pablo Landgraf: The Rockefeller University
Nicola Iovino: The Rockefeller University
Patricia Morris: Population Council, The Rockefeller University
Michael J. Brownstein: J. Craig Venter Institute, Functional Genomics
Satomi Kuramochi-Miyagawa: Graduate School of Frontier Biosciences, Osaka University
Toru Nakano: Graduate School of Frontier Biosciences, Osaka University
Minchen Chien: Columbia Genome Center, Russ Berrie Pavilion
James J. Russo: Columbia Genome Center, Russ Berrie Pavilion
Jingyue Ju: Columbia Genome Center, Russ Berrie Pavilion
Robert Sheridan: Computational Biology Center, Memorial Sloan-Kettering Cancer Center
Chris Sander: Computational Biology Center, Memorial Sloan-Kettering Cancer Center
Mihaela Zavolan: Biozentrum, Universität Basel
Thomas Tuschl: The Rockefeller University

Nature, 2006, vol. 442, issue 7099, 203-207

Abstract: A new type of RNAi In RNA interference, small RNAs (siRNAs or miRNAs) act to regulate gene expression. They serve as specificity factors that direct the RISC (RNA-induced silencing) complex to the complementary mRNA targets. A major component of RISC is a protein of the Argonaute family. Two groups have now identified a new class of small RNAs that interact with one Argonaute subfamily, the Piwi class. These testis-specific small RNAs, called 'piRNAs', are slightly longer than the previously described small RNAs. The function of the piRNAs is not yet known, but they might be involved in sperm production.

Date: 2006
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DOI: 10.1038/nature04916

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