A germline-specific class of small RNAs binds mammalian Piwi proteins

Angélique Girard, Ravi Sachidanandam, Gregory J. Hannon () and Michelle A. Carmell
Additional contact information
Angélique Girard: Watson School of Biological Sciences
Ravi Sachidanandam: Watson School of Biological Sciences
Gregory J. Hannon: Watson School of Biological Sciences
Michelle A. Carmell: Watson School of Biological Sciences

Nature, 2006, vol. 442, issue 7099, 199-202

Abstract: A new type of RNAi In RNA interference, small RNAs (siRNAs or miRNAs) act to regulate gene expression. They serve as specificity factors that direct the RISC (RNA-induced silencing) complex to the complementary mRNA targets. A major component of RISC is a protein of the Argonaute family. Two groups have now identified a new class of small RNAs that interact with one Argonaute subfamily, the Piwi class. These testis-specific small RNAs, called 'piRNAs', are slightly longer than the previously described small RNAs. The function of the piRNAs is not yet known, but they might be involved in sperm production.

Date: 2006
References: Add references at CitEc
Citations: View citations in EconPapers (6)

Downloads: (external link)
https://www.nature.com/articles/nature04917 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:442:y:2006:i:7099:d:10.1038_nature04917

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature04917

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().