Atom-by-atom analysis of global downhill protein folding

Mourad Sadqi, David Fushman and Victor Muñoz ()
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Mourad Sadqi: University of Maryland
David Fushman: University of Maryland
Victor Muñoz: University of Maryland

Nature, 2006, vol. 442, issue 7100, 317-321

Abstract: Atom-by-atom folding In the past, protein folding has been more approachable via theory than via experiment. But recently, theory has begun to be confirmed experimentally. In contrast to the belief that all proteins fold in one sudden movement, some in fact fold and unfold gradually, in a random series of steps called downhill folding. Sadqi et al. have used a novel NMR approach to monitor unfolding of a protein atom-by-atom from the native state. The results have greater resolution than had been previously achieved, and confirm that folding is a statistical process best understood by a downhill landscape funnel model. In addition, cooperativity can be understood by mapping the atomic interactions within a protein.

Date: 2006
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DOI: 10.1038/nature04859

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