Kruppel-like factor 2 regulates thymocyte and T-cell migration

Corey M. Carlson, Bart T. Endrizzi, Jinghai Wu, Xiaojie Ding, Michael A. Weinreich, Elizabeth R. Walsh, Maqsood A. Wani, Jerry B. Lingrel, Kristin A. Hogquist () and Stephen C. Jameson ()
Additional contact information
Corey M. Carlson: University of Minnesota Medical School
Bart T. Endrizzi: University of Minnesota Medical School
Jinghai Wu: University of Cincinnati
Xiaojie Ding: University of Minnesota Medical School
Michael A. Weinreich: University of Minnesota Medical School
Elizabeth R. Walsh: University of Minnesota Medical School
Maqsood A. Wani: University of Cincinnati
Jerry B. Lingrel: University of Cincinnati
Kristin A. Hogquist: University of Minnesota Medical School
Stephen C. Jameson: University of Minnesota Medical School

Nature, 2006, vol. 442, issue 7100, 299-302

Abstract: A new role for KLF2 The transcription factor KLF2 has long been thought to play a critical role in controlling survival and quiescence of mature T cells, since KLF2-deficient T cells develop in the thymus but fail to populate peripheral lymph organs. A new study offers an alternative explanation for this phenotype, consistent with an entirely different function for KLF2 as a regulator of thymocyte and T-cell migration. Proteins of the KLF (Krüppel-like transcription factor) family are involved in many aspects of vertebrate development and are implicated in a number of disease states. This newly discovered role for KLF2 is similar to some other KLFs that are essential for terminal differentiation of various cell types.

Date: 2006
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DOI: 10.1038/nature04882

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