IL-23 promotes tumour incidence and growth

John L. Langowski, Xueqing Zhang, Lingling Wu, Jeanine D. Mattson, Taiying Chen, Kathy Smith, Beth Basham, Terrill McClanahan, Robert A. Kastelein and Martin Oft ()
Additional contact information
John L. Langowski: Schering-Plough BioPharma (formerly DNAX Research, Inc.)
Xueqing Zhang: Schering-Plough BioPharma (formerly DNAX Research, Inc.)
Lingling Wu: Schering-Plough BioPharma (formerly DNAX Research, Inc.)
Jeanine D. Mattson: Schering-Plough BioPharma (formerly DNAX Research, Inc.)
Taiying Chen: Schering-Plough BioPharma (formerly DNAX Research, Inc.)
Kathy Smith: Schering-Plough BioPharma (formerly DNAX Research, Inc.)
Beth Basham: Schering-Plough BioPharma (formerly DNAX Research, Inc.)
Terrill McClanahan: Schering-Plough BioPharma (formerly DNAX Research, Inc.)
Robert A. Kastelein: Schering-Plough BioPharma (formerly DNAX Research, Inc.)
Martin Oft: Schering-Plough BioPharma (formerly DNAX Research, Inc.)

Nature, 2006, vol. 442, issue 7101, 461-465

Abstract: Missing link A long-sought link between cancer and inflammation has been found. Inflammation triggered by interleukin-23(IL-23), which is present in many human tumours, seems to help tumours grow by protecting them from the immune system and by promoting blood vessel formation. Mice born without IL-23 are protected against cancer, as are mice in which IL-23 is blocked by antibodies, suggesting that a similar strategy might be possible against human cancers.

Date: 2006
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DOI: 10.1038/nature04808

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