Endothelial tubes assemble from intracellular vacuoles in vivo

Makoto Kamei, W. Brian Saunders, Kayla J. Bayless, Louis Dye, George E. Davis and Brant M. Weinstein
Additional contact information
Makoto Kamei: Laboratory of Molecular Genetics
W. Brian Saunders: Texas A&M University System Health Science Center
Kayla J. Bayless: Texas A&M University System Health Science Center
Louis Dye: Microscopy and Imaging Core, National Institute of Child Health and Human Development, National Institutes of Health
George E. Davis: Texas A&M University System Health Science Center
Brant M. Weinstein: Laboratory of Molecular Genetics

Nature, 2006, vol. 442, issue 7101, 453-456

Abstract: Tubular cells Epithelial tubes are important structural components in many different tissues, including the vascular system, where because of the interest in angiogenesis inhibitors as anticancer drugs, they are pharmacologically important too. It has been difficult to establish their exact mechanism of formation. Now high resolution time-lapse imaging of blood vessel formation in living (and conveniently transparent) zebrafish shows that the lumen of the blood vessels is formed by coalescence of intracellular vacuoles, followed by fusion to the plasma membrane. The study finally provides in vivo confirmation of the century-old fusion model for endothelial lumen formation, and finally lays to rest alternative models and concerns about cell culture artefacts.

Date: 2006
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DOI: 10.1038/nature04923

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