Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN

Min Zhao (), Bing Song, Jin Pu, Teiji Wada, Brian Reid, Guangping Tai, Fei Wang, Aihua Guo, Petr Walczysko, Yu Gu, Takehiko Sasaki, Akira Suzuki, John V. Forrester, Henry R. Bourne, Peter N. Devreotes, Colin D. McCaig and Josef M. Penninger ()
Additional contact information
Min Zhao: University of Aberdeen
Bing Song: University of Aberdeen
Jin Pu: University of Aberdeen
Teiji Wada: Institute of Molecular Biotechnology of the Austrian Academy of Sciences
Brian Reid: University of Aberdeen
Guangping Tai: University of Aberdeen
Fei Wang: University of California
Aihua Guo: University of Aberdeen
Petr Walczysko: University of Aberdeen
Yu Gu: University of Aberdeen
Takehiko Sasaki: Akita University School of Medicine
Akira Suzuki: Akita University School of Medicine
John V. Forrester: University of Aberdeen
Henry R. Bourne: University of California
Peter N. Devreotes: Johns Hopkins University School of Medicine
Colin D. McCaig: University of Aberdeen
Josef M. Penninger: Institute of Molecular Biotechnology of the Austrian Academy of Sciences

Nature, 2006, vol. 442, issue 7101, 457-460

Abstract: Healing potential The disruption of the epithelium in all animals tested generates an endogenous electric current, and the cells involved in wound healing are known to respond to applied electrical signals. Wound-induced currents have been known for more than 150 years but their role in wound healing has largely been discounted. New work in mice and in tissue culture shows that electric fields can provide directional cues for cell movement during wound healing and identifies specific genes that are involved, which should lead to a more positive attitude to this intriguing phenomenon. The molecules central to this finding are phosphatidylinositol 3′-kinase-γ(PI3Kγ) and the tumour suppressor PTEN, which have been found to be required for the directed movements of 'healing' cells in response to electrical signals.

Date: 2006
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DOI: 10.1038/nature04925

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