P2X receptors as cell-surface ATP sensors in health and disease

Baljit S. Khakh () and R. Alan North ()
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Baljit S. Khakh: Medical Research Council Laboratory of Molecular Biology
R. Alan North: University of Manchester

Nature, 2006, vol. 442, issue 7102, 527-532

Abstract: Abstract P2X receptors are membrane ion channels activated by the binding of extracellular adenosine triphosphate (ATP). For years their functional significance was consigned to distant regions of the autonomic nervous system, but recent work indicates several further key roles, such as afferent signalling, chronic pain, and in autocrine loops of endothelial and epithelial cells. P2X receptors have a molecular architecture distinct from other ion channel protein families, and have several unique functional properties.

Date: 2006
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DOI: 10.1038/nature04886

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