Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein

Fanny Pilot, Jean-Marc Philippe, Céline Lemmers and Thomas Lecuit ()
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Fanny Pilot: CNRS-Université de la Méditerrannée. Campus de Luminy
Jean-Marc Philippe: CNRS-Université de la Méditerrannée. Campus de Luminy
Céline Lemmers: CNRS-Université de la Méditerrannée. Campus de Luminy
Thomas Lecuit: CNRS-Université de la Méditerrannée. Campus de Luminy

Nature, 2006, vol. 442, issue 7102, 580-584

Abstract: The synaptotagmin-like protein Bitesize spatially controls F-actin at adherens junctions of the Drosophila primary embryonic epithelium independent of E-cadherin. The polarity cues Par-3 and Phosphatidylinositol (4,5)-biphosphate localize Bitesize in the junctional area. Bitesize binds the F-actin-binding protein Moesin, and thereby controls junction stability.

Date: 2006
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DOI: 10.1038/nature04935

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