Enzymatic activation of voltage-gated potassium channels

Yajamana Ramu, Yanping Xu and Zhe Lu ()
Additional contact information
Yajamana Ramu: University of Pennsylvania
Yanping Xu: University of Pennsylvania
Zhe Lu: University of Pennsylvania

Nature, 2006, vol. 442, issue 7103, 696-699

Abstract: Abstract Voltage-gated ion channels in excitable nerve, muscle, and endocrine cells generate electric signals in the form of action potentials1. However, they are also present in non-excitable eukaryotic cells and prokaryotes, which raises the question of whether voltage-gated channels might be activated by means other than changing the voltage difference between the solutions separated by the plasma membrane. The search for so-called voltage-gated channel activators is motivated in part by the growing importance of such agents in clinical pharmacology. Here we report the apparent activation of voltage-gated K+ (Kv) channels by a sphingomyelinase.

Date: 2006
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature04880 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:442:y:2006:i:7103:d:10.1038_nature04880

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature04880

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().