Assembly dynamics of microtubules at molecular resolution

Jacob W. J. Kerssemakers, E. Laura Munteanu, Liedewij Laan, Tim L. Noetzel, Marcel E. Janson and Marileen Dogterom ()
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Jacob W. J. Kerssemakers: Foundation for Fundamental Research on Matter (FOM) Institute for Atomic and Molecular Physics (AMOLF)
E. Laura Munteanu: Foundation for Fundamental Research on Matter (FOM) Institute for Atomic and Molecular Physics (AMOLF)
Liedewij Laan: Foundation for Fundamental Research on Matter (FOM) Institute for Atomic and Molecular Physics (AMOLF)
Tim L. Noetzel: Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) Dresden
Marcel E. Janson: Foundation for Fundamental Research on Matter (FOM) Institute for Atomic and Molecular Physics (AMOLF)
Marileen Dogterom: Foundation for Fundamental Research on Matter (FOM) Institute for Atomic and Molecular Physics (AMOLF)

Nature, 2006, vol. 442, issue 7103, 709-712

Abstract: A single-molecule approach was used to observe the growth dynamics of individual microtubules. Observations suggest that small tubulin oligomers can add directly to growing microtubules, and that the protein XMAP215 facilitates the addition of longer oligomers.

Date: 2006
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DOI: 10.1038/nature04928

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