An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

Fajun Yang, Bryan W. Vought, John S. Satterlee, Amy K. Walker, Z.-Y. Jim Sun, Jennifer L. Watts, Rosalie DeBeaumont, R. Mako Saito, Sven G. Hyberts, Shaosong Yang, Christine Macol, Lakshmanan Iyer, Robert Tjian, Sander van den Heuvel, Anne C. Hart, Gerhard Wagner and Anders M. Näär ()
Additional contact information
Fajun Yang: Massachusetts General Hospital Cancer Center
Bryan W. Vought: Department of Biological Chemistry and Molecular Pharmacology
John S. Satterlee: Massachusetts General Hospital Cancer Center
Amy K. Walker: Massachusetts General Hospital Cancer Center
Z.-Y. Jim Sun: Department of Biological Chemistry and Molecular Pharmacology
Jennifer L. Watts: Washington State University
Rosalie DeBeaumont: Massachusetts General Hospital Cancer Center
R. Mako Saito: Massachusetts General Hospital Cancer Center
Sven G. Hyberts: Department of Biological Chemistry and Molecular Pharmacology
Shaosong Yang: Massachusetts General Hospital Cancer Center
Christine Macol: Massachusetts General Hospital Cancer Center
Lakshmanan Iyer: Harvard University
Robert Tjian: Department of Molecular and Cell Biology, UC Berkeley
Sander van den Heuvel: Massachusetts General Hospital Cancer Center
Anne C. Hart: Massachusetts General Hospital Cancer Center
Gerhard Wagner: Department of Biological Chemistry and Molecular Pharmacology
Anders M. Näär: Massachusetts General Hospital Cancer Center

Nature, 2006, vol. 442, issue 7103, 700-704

Abstract: A subunit of the ARC/Mediator co-activator complex is a key effector of the SREBP transcription factor during regulation of lipid homeostasis in human cells and Caenorhabditis elegans. The SREBP activation domain directly targets a KIX domain on ARC105/MED15

Date: 2006
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DOI: 10.1038/nature04942

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