Notch signalling regulates stem cell numbers in vitro and in vivo

Andreas Androutsellis-Theotokis, Ronen R. Leker, Frank Soldner, Daniel J. Hoeppner, Rea Ravin, Steve W. Poser, Maria A. Rueger, Soo-Kyung Bae, Raja Kittappa and Ronald D. G. McKay ()
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Andreas Androutsellis-Theotokis: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Ronen R. Leker: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Frank Soldner: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Daniel J. Hoeppner: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Rea Ravin: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Steve W. Poser: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Maria A. Rueger: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Soo-Kyung Bae: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Raja Kittappa: National Institute of Neurological Disorders and Stroke, National Institutes of Health
Ronald D. G. McKay: National Institute of Neurological Disorders and Stroke, National Institutes of Health

Nature, 2006, vol. 442, issue 7104, 823-826

Abstract: Stem cells go up a Notch One barrier to using stem cells for therapies is the difficulty in controlling their growth and differentiation. Androutsellis-Theotokis et al. show that the Notch receptor plays a pivotal role in a pathway that controls the survival of embryonic, fetal and adult stem cells, and that administration of Notch ligands to the brains of adult rats can help the animals recover movement after a simulated stroke. The finding paves the way towards therapies that aim to encourage the body's endogenous stem cells to repair damage, rather than trying to grow and transplant new cells.

Date: 2006
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DOI: 10.1038/nature04940

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