Nondisjunction, aneuploidy and tetraploidy

Beth A. A. Weaver, Alain D. Silk and Don W. Cleveland ()
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Beth A. A. Weaver: University of California, San Diego
Alain D. Silk: University of California, San Diego
Don W. Cleveland: University of California, San Diego

Nature, 2006, vol. 442, issue 7104, E9-E10

Abstract: Abstract Arising from: Q. Shi & R. W. King Nature 437, 1038–1042 (2005); Shi & King reply One simple, widely accepted mechanism for generating an aberrant chromosome number, or aneuploidy, is through nondisjunction — a chromosome distribution error that occurs during mitosis when both copies of a duplicated chromosome are deposited into one daughter cell and none into the other. Shi and King1 challenge this view, concluding that nondisjunction does not yield aneuploid cells directly, but instead gives rise to tetraploid cells that may subsequently become aneuploid through further division. Here we show that the direct result of chromosome nondisjunction is gain or loss of a single chromosome, which results in near-diploid aneuploidy, not tetraploidy. We suggest that chromatin trapped in the cytokinetic cleavage furrow is the more likely reason for furrow regression and tetraploidization.

Date: 2006
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DOI: 10.1038/nature05139

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