Nondisjunction, aneuploidy and tetraploidy (Reply)

Qinghua Shi and Randall W. King ()
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Qinghua Shi: University of Science and Technology of China
Randall W. King: Harvard Medical School

Nature, 2006, vol. 442, issue 7104, E10-E10

Abstract: Abstract Weaver et al. report1 that chromosome nondisjunction induced by knockout of the mitosis-specific motor protein CENP-E does not increase the rate of binucleation in mouse fibroblasts and conclude that nondisjunction is therefore not coupled to furrow regression. However, they have not yet excluded alternative interpretations of their results, which makes it hard to compare them directly to our findings. Critical confounding issues include analysis of different cell types and the use of a specific gene deletion, for which corresponding naturally occurring mutations have not been described.

Date: 2006
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DOI: 10.1038/nature05140

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