Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

Matt Baker, Ian R. Mackenzie (), Stuart M. Pickering-Brown, Jennifer Gass, Rosa Rademakers, Caroline Lindholm, Julie Snowden, Jennifer Adamson, A. Dessa Sadovnick, Sara Rollinson, Ashley Cannon, Emily Dwosh, David Neary, Stacey Melquist, Anna Richardson, Dennis Dickson, Zdenek Berger, Jason Eriksen, Todd Robinson, Cynthia Zehr, Chad A. Dickey, Richard Crook, Eileen McGowan, David Mann, Bradley Boeve, Howard Feldman and Mike Hutton ()
Additional contact information
Matt Baker: Mayo Clinic College of Medicine
Ian R. Mackenzie: Department of Pathology
Stuart M. Pickering-Brown: University of Manchester
Jennifer Gass: Mayo Clinic College of Medicine
Rosa Rademakers: Mayo Clinic College of Medicine
Caroline Lindholm: Division of Neurology
Julie Snowden: University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital
Jennifer Adamson: Mayo Clinic College of Medicine
A. Dessa Sadovnick: Division of Neurology
Sara Rollinson: University of Manchester
Ashley Cannon: Mayo Clinic College of Medicine
Emily Dwosh: Department of Medical Genetics, University of British Columbia
David Neary: University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital
Stacey Melquist: Mayo Clinic College of Medicine
Anna Richardson: University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital
Dennis Dickson: Mayo Clinic College of Medicine
Zdenek Berger: Mayo Clinic College of Medicine
Jason Eriksen: Mayo Clinic College of Medicine
Todd Robinson: Mayo Clinic College of Medicine
Cynthia Zehr: Mayo Clinic College of Medicine
Chad A. Dickey: Mayo Clinic College of Medicine
Richard Crook: Mayo Clinic College of Medicine
Eileen McGowan: Mayo Clinic College of Medicine
David Mann: University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital
Bradley Boeve: Mayo Clinic College of Medicine
Howard Feldman: Division of Neurology
Mike Hutton: Mayo Clinic College of Medicine

Nature, 2006, vol. 442, issue 7105, 916-919

Abstract: Dementia-causing mutation Two groups of neuroscientists have discovered that a mutation in the progranulin gene, which encodes a growth factor, can cause frontotemporal dementia (FTD). The condition, the second most common form of dementia among under-65s, impairs memory and personality and may also affect movement. The discovery may help to resolve confusion over the cause of the disease — mutations in a neighbouring gene called microtubule-associated protein tau were shown previously to be associated with some, but not all, cases of FTD.

Date: 2006
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DOI: 10.1038/nature05016

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