Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Marc Cruts, Ilse Gijselinck, Julie van der Zee, Sebastiaan Engelborghs, Hans Wils, Daniel Pirici, Rosa Rademakers, Rik Vandenberghe, Bart Dermaut, Jean-Jacques Martin, Cornelia van Duijn, Karin Peeters, Raf Sciot, Patrick Santens, Tim De Pooter, Maria Mattheijssens, Marleen Van den Broeck, Ivy Cuijt, Krist'l Vennekens, Peter P. De Deyn, Samir Kumar-Singh and Christine Van Broeckhoven ()
Additional contact information
Marc Cruts: Flanders Interuniversity Institute for Biotechnology
Ilse Gijselinck: Flanders Interuniversity Institute for Biotechnology
Julie van der Zee: Flanders Interuniversity Institute for Biotechnology
Sebastiaan Engelborghs: Laboratory of Neurochemistry and Behavior
Hans Wils: Flanders Interuniversity Institute for Biotechnology
Daniel Pirici: Flanders Interuniversity Institute for Biotechnology
Rosa Rademakers: Flanders Interuniversity Institute for Biotechnology
Rik Vandenberghe: Department of Neurology
Bart Dermaut: Ghent University Hospital, Ghent University
Jean-Jacques Martin: Laboratory of Neuropathology, Institute Born-Bunge
Cornelia van Duijn: Erasmus Medical Center Rotterdam
Karin Peeters: Flanders Interuniversity Institute for Biotechnology
Raf Sciot: University Hospital Gasthuisberg, Katholieke Universiteit Leuven (KULeuven)
Patrick Santens: Ghent University Hospital, Ghent University
Tim De Pooter: Flanders Interuniversity Institute for Biotechnology
Maria Mattheijssens: Flanders Interuniversity Institute for Biotechnology
Marleen Van den Broeck: Flanders Interuniversity Institute for Biotechnology
Ivy Cuijt: Flanders Interuniversity Institute for Biotechnology
Krist'l Vennekens: Flanders Interuniversity Institute for Biotechnology
Peter P. De Deyn: Laboratory of Neurochemistry and Behavior
Samir Kumar-Singh: Flanders Interuniversity Institute for Biotechnology
Christine Van Broeckhoven: Flanders Interuniversity Institute for Biotechnology

Nature, 2006, vol. 442, issue 7105, 920-924

Abstract: Dementia-causing mutation Two groups of neuroscientists have discovered that a mutation in the progranulin gene, which encodes a growth factor, can cause frontotemporal dementia (FTD). The condition, the second most common form of dementia among under-65s, impairs memory and personality and may also affect movement. The discovery may help to resolve confusion over the cause of the disease — mutations in a neighbouring gene called microtubule-associated protein tau were shown previously to be associated with some, but not all, cases of FTD.

Date: 2006
References: Add references at CitEc
Citations: View citations in EconPapers (6)

Downloads: (external link)
https://www.nature.com/articles/nature05017 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:442:y:2006:i:7105:d:10.1038_nature05017

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature05017

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().