NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus

Ayumu Tashiro, Vladislav M. Sandler, Nicolas Toni, Chunmei Zhao and Fred H. Gage ()
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Ayumu Tashiro: The Salk Institute for Biological Studies
Vladislav M. Sandler: The Salk Institute for Biological Studies
Nicolas Toni: The Salk Institute for Biological Studies
Chunmei Zhao: The Salk Institute for Biological Studies
Fred H. Gage: The Salk Institute for Biological Studies

Nature, 2006, vol. 442, issue 7105, 929-933

Abstract: Well connected New neurons are continuously added to the adult brain but how this affects brain function is unclear. By developing a new single-cell gene knock-out technique, Tashiro et al. show that new neurons are selected for survival depending on their synaptic input. This provides a possible mechanism for the building of new yet consistent neuronal circuits during learning and memory. In the image above, new neurons in adult dentate gyrus are visualized by retrovirus-mediated expression of green fluorescence protein. The dentate granule and CA3 pyramidal cell layers were visualized by immunostaining for NeuN.

Date: 2006
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DOI: 10.1038/nature05028

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