Causes of trends in amino-acid gain and loss (Reply)

I. K. Jordan, F. A. Kondrashov, I. A. Adzhubei, Y. I. Wolf, E. V. Koonin, A. S. Kondrashov and S. Sunyaev ()
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I. K. Jordan: National Center for Biotechnology Information, National Institutes of Health
F. A. Kondrashov: Section of Evolution and Ecology, University of California
I. A. Adzhubei: Brigham & Women's Hospital, Harvard Medical School
Y. I. Wolf: National Center for Biotechnology Information, National Institutes of Health
E. V. Koonin: National Center for Biotechnology Information, National Institutes of Health
A. S. Kondrashov: National Center for Biotechnology Information, National Institutes of Health
S. Sunyaev: Brigham & Women's Hospital, Harvard Medical School

Nature, 2006, vol. 442, issue 7105, E12-E12

Abstract: Abstract Hurst et al .1 and, earlier, McDonald2 confirm the pattern of amino-acid gain and loss that we report3. However, they attribute this pattern to properties of the mutation-selection equilibrium, arguing that gainer amino acids are more common than losers among weakly deleterious, rare polymorphisms, which segregate within one or both compared species but never reach fixation. Indeed, we all1,2,3 concur that gainers are, mostly, under-represented, whereas losers are over-represented with respect to mutations ( Table 3 of ref. 3). Still, we cannot agree that the effect of weak negative selection is a viable alternative to our original explanation.

Date: 2006
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DOI: 10.1038/nature05138

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