Sperm chromatin proteomics identifies evolutionarily conserved fertility factors

Diana S. Chu (), Hongbin Liu, Paola Nix, Tammy F. Wu, Edward J. Ralston, John R. Yates and Barbara J. Meyer
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Diana S. Chu: San Francisco State University
Hongbin Liu: The Scripps Research Institute
Paola Nix: University of California, Berkeley
Tammy F. Wu: San Francisco State University
Edward J. Ralston: University of California, Berkeley
John R. Yates: The Scripps Research Institute
Barbara J. Meyer: University of California, Berkeley

Nature, 2006, vol. 443, issue 7107, 101-105

Abstract: Fertility factors The identification of conserved proteins important for sperm chromatin structure and packaging can reveal possible causes of male fertility of clinical importance. A proteomics strategy in the nematode Caenorhabditis elegans has been used to identify a series of spermatogenesis-specific factors that are required for DNA compaction, chromosome segregation and fertility, many of which cause male sterility in mice. The resulting list of proteins will provide new opportunities to identify the causes of male sterility and could also provide possible targets for male contraceptives. The cover image shows nuclei progressing through spermatogenesis in a C. elegans male gonad, which has been fixed and stained with fluorescent markers. DNA is shown in red. Sperm protamines SPCH-1, SPCH-2 and SPCH-3 are shown in green. Yellow in the image indicates colocalization.

Date: 2006
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DOI: 10.1038/nature05050

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