Soma–germline interactions coordinate homeostasis and growth in the Drosophila gonad

Lilach Gilboa and Ruth Lehmann ()
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Lilach Gilboa: The Skirball Institute and Department of Cell Biology, New York University School of Medicine
Ruth Lehmann: The Skirball Institute and Department of Cell Biology, New York University School of Medicine

Nature, 2006, vol. 443, issue 7107, 97-100

Abstract: Examining how the division rate of primordial germ cells (PGCs) in the fly ovary is controlled finds that there is a feedback loop composed of positive and negative signals, whereby PGCs express an EGF ligand called Spitz, which is essential for survival of adjacent somatic cells, and the somatic cells in turn inhibit PGC proliferation.

Date: 2006
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DOI: 10.1038/nature05068

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