Enantioselective silyl protection of alcohols catalysed by an amino-acid-based small molecule

Yu Zhao, Jason Rodrigo, Amir H. Hoveyda () and Marc L. Snapper ()
Additional contact information
Yu Zhao: Merkert Chemistry Center, Boston College
Jason Rodrigo: Merkert Chemistry Center, Boston College
Amir H. Hoveyda: Merkert Chemistry Center, Boston College
Marc L. Snapper: Merkert Chemistry Center, Boston College

Nature, 2006, vol. 443, issue 7107, 67-70

Abstract: Chiral synthesis made easy Reliable, selective, and environmentally friendly chemical reactions are often needed to efficiently synthesize natural products and therapeutics. Although a number of catalysts are available for such syntheses, chemists often search for new ones that can produce organic molecules in high yields and high enantiomeric purity. Zhao et al. have now developed a simple metal-free catalyst that can be used to protect a specific alcohol with a silyl protecting group without modifying another alcohol nearby. They obtained high yields and enantioselectivities for a number of substrates and hope that this catalyst could lead to new 'green' catalysts capable of producing important organic molecules.

Date: 2006
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/nature05102 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:443:y:2006:i:7107:d:10.1038_nature05102

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/nature05102

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().