Structure of the insulin receptor ectodomain reveals a folded-over conformation

Neil M. McKern, Michael C. Lawrence (), Victor A. Streltsov, Mei-Zhen Lou, Timothy E. Adams, George O. Lovrecz, Thomas C. Elleman, Kim M. Richards, John D. Bentley, Patricia A. Pilling, Peter A. Hoyne, Kellie A. Cartledge, Tam M. Pham, Jennifer L. Lewis, Sonia E. Sankovich, Violet Stoichevska, Elizabeth Da Silva, Christine P. Robinson, Maurice J. Frenkel, Lindsay G. Sparrow, Ross T. Fernley, V. Chandana Epa and Colin W. Ward ()
Additional contact information
Neil M. McKern: CSIRO Molecular & Health Technologies
Michael C. Lawrence: CSIRO Molecular & Health Technologies
Victor A. Streltsov: CSIRO Molecular & Health Technologies
Mei-Zhen Lou: CSIRO Molecular & Health Technologies
Timothy E. Adams: CSIRO Molecular & Health Technologies
George O. Lovrecz: CSIRO Molecular & Health Technologies
Thomas C. Elleman: CSIRO Molecular & Health Technologies
Kim M. Richards: CSIRO Molecular & Health Technologies
John D. Bentley: CSIRO Molecular & Health Technologies
Patricia A. Pilling: CSIRO Molecular & Health Technologies
Peter A. Hoyne: CSIRO Molecular & Health Technologies
Kellie A. Cartledge: CSIRO Molecular & Health Technologies
Tam M. Pham: CSIRO Molecular & Health Technologies
Jennifer L. Lewis: CSIRO Molecular & Health Technologies
Sonia E. Sankovich: CSIRO Molecular & Health Technologies
Violet Stoichevska: CSIRO Molecular & Health Technologies
Elizabeth Da Silva: CSIRO Molecular & Health Technologies
Christine P. Robinson: CSIRO Molecular & Health Technologies
Maurice J. Frenkel: CSIRO Molecular & Health Technologies
Lindsay G. Sparrow: CSIRO Molecular & Health Technologies
Ross T. Fernley: CSIRO Molecular & Health Technologies
V. Chandana Epa: CSIRO Molecular & Health Technologies
Colin W. Ward: CSIRO Molecular & Health Technologies

Nature, 2006, vol. 443, issue 7108, 218-221

Abstract: Insulin receptor second site The first report of the crystal structure of the whole insulin receptor ectodomain dimer reveals how its multiple domains are organized. The structure also identifies the elusive second binding site on the receptor, and suggests how the high-affinity insulin–receptor complex, which leads to signal induction, is generated. The structure as now published differs dramatically from previous versions based on reconstructions from cryoelectron microscopy data.

Date: 2006
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DOI: 10.1038/nature05106

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