An intron with a constitutive transport element is retained in a Tap messenger RNA

Ying Li, Yeou-cherng Bor, Yukiko Misawa, Yuming Xue, David Rekosh and Marie-Louise Hammarskjöld ()
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Ying Li: University of Virginia
Yeou-cherng Bor: University of Virginia
Yukiko Misawa: University of Virginia
Yuming Xue: University of Virginia
David Rekosh: University of Virginia
Marie-Louise Hammarskjöld: University of Virginia

Nature, 2006, vol. 443, issue 7108, 234-237

Abstract: This study identifies an mRNA encoding the host protein Tap that retains an intron when exported to the cytoplasm. A protein containing this intron is produced, although the function of this form isn't known. In a circular twist, the mechanism by which export of the intron occurs involves a CTE element in the mRNA, which binds the Tap protein.

Date: 2006
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DOI: 10.1038/nature05107

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