Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

Andriy V. Yeromin, Shenyuan L. Zhang, Weihua Jiang, Ying Yu, Olga Safrina and Michael D. Cahalan ()
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Andriy V. Yeromin: University of California
Shenyuan L. Zhang: University of California
Weihua Jiang: University of California
Ying Yu: University of California
Olga Safrina: University of California
Michael D. Cahalan: University of California

Nature, 2006, vol. 443, issue 7108, 226-229

Abstract: Calcium pump Two groups report the molecular identification of the long-sought CRAC channel as a plasma membrane protein known variously as olf186-F, Orai and CRACM1. The CRAC channel is of fundamental importance to Ca2+ signalling mechanisms in cell biology.

Date: 2006
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DOI: 10.1038/nature05108

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