Orai1 is an essential pore subunit of the CRAC channel

Murali Prakriya, Stefan Feske, Yousang Gwack, Sonal Srikanth, Anjana Rao () and Patrick G. Hogan
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Murali Prakriya: Northwestern University, Feinberg School of Medicine
Stefan Feske: Harvard Medical School and the CBR Institute for Biomedical Research
Yousang Gwack: Harvard Medical School and the CBR Institute for Biomedical Research
Sonal Srikanth: Harvard Medical School and the CBR Institute for Biomedical Research
Anjana Rao: Harvard Medical School and the CBR Institute for Biomedical Research
Patrick G. Hogan: Harvard Medical School and the CBR Institute for Biomedical Research

Nature, 2006, vol. 443, issue 7108, 230-233

Abstract: Calcium pump Two groups report the molecular identification of the long-sought CRAC channel as a plasma membrane protein known variously as olf186-F, Orai and CRACM1. The CRAC channel is of fundamental importance to Ca2+ signalling mechanisms in cell biology.

Date: 2006
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DOI: 10.1038/nature05122

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