Central nervous system control of food intake and body weight

G. J. Morton, D. E. Cummings, D. G. Baskin, G. S. Barsh and M. W. Schwartz ()
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G. J. Morton: Harborview Medical Center and University of Washington
D. E. Cummings: Veterans Affairs Puget Sound Health Care System and University of Washington
D. G. Baskin: Veterans Affairs Puget Sound Health Care System and University of Washington
G. S. Barsh: Stanford University School of Medicine
M. W. Schwartz: Harborview Medical Center and University of Washington

Nature, 2006, vol. 443, issue 7109, 289-295

Abstract: Abstract The capacity to adjust food intake in response to changing energy requirements is essential for survival. Recent progress has provided an insight into the molecular, cellular and behavioural mechanisms that link changes of body fat stores to adaptive adjustments of feeding behaviour. The physiological importance of this homeostatic control system is highlighted by the severe obesity that results from dysfunction of any of several of its key components. This new information provides a biological context within which to consider the global obesity epidemic and identifies numerous potential avenues for therapeutic intervention and future research.

Date: 2006
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DOI: 10.1038/nature05026

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