Topical drug rescue strategy and skin protection based on the role of Mc1r in UV-induced tanning

John A. D'Orazio, Tetsuji Nobuhisa, Rutao Cui, Michelle Arya, Malinda Spry, Kazumasa Wakamatsu, Vivien Igras, Takahiro Kunisada, Scott R. Granter, Emi K. Nishimura, Shosuke Ito and David E. Fisher ()
Additional contact information
John A. D'Orazio: Melanoma Program
Tetsuji Nobuhisa: Melanoma Program
Rutao Cui: Melanoma Program
Michelle Arya: Melanoma Program
Malinda Spry: Markey Cancer Center and the Graduate Center for Toxicology, University of Kentucky College of Medicine
Kazumasa Wakamatsu: Fujita Health University, School of Health Sciences
Vivien Igras: Melanoma Program
Takahiro Kunisada: Gifu University, Graduate School of Medicine
Scott R. Granter: Melanoma Program
Emi K. Nishimura: Melanoma Program
Shosuke Ito: Fujita Health University, School of Health Sciences
David E. Fisher: Melanoma Program

Nature, 2006, vol. 443, issue 7109, 340-344

Abstract: An antitumour tan? Fair-skinned individuals suffer an increased risk of skin cancer and often have a weak tanning response. D'Orazio et al. have developed a genetically defined mouse model of skin 'fairness' based on the Mc1r gene (for melanocortin 1 receptor), which is implicated in fair-skinned humans. UV-induced pigmentation (tanning) in these mice was found to involve keratinocyte expression of melanocyte stimulating hormone. 'Sunless tanning' induced by topical application of a small molecule that mimics this enhanced melanocortin 1 receptor signalling can stimulate pigmentation and thereby protect mice with light skin from DNA damage and cancer formation.

Date: 2006
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DOI: 10.1038/nature05098

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